ONCAlert | 2017 San Antonio Breast Cancer Symposium
Hepatocellular Carcinoma Case Studies

Case Studies: Long-Term Strategies in Advanced HCC

In this case-based interview, Ghassan Abou-Alfa, MD, describes the case of a 70-year old male with metastatic HCC involving the lung and bone who progresses following therapy with sorafenib.

Long-Term Strategies in Advanced HCC

May 2016

  • A 70-year old male with metastatic HCC involving the lung and bone confirmed by biopsy, experiencing mild bone pain
  • ECOG=1
  • Child-Pugh A
  • Therapy was initiated with sorafenib at 400 BID
  • Patient experienced grade 1 HTN and grade 1 hand-foot skin reaction, which was managed effectively

April 2017

  • Documented radiographic progression
  • Therapy with regorafenib at 160mg was initiated
  • Patient experienced grade 1 HTN, grade 2 hand-foot skin reaction
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