ONCAlert | 2017 San Antonio Breast Cancer Symposium
Hepatocellular Carcinoma Case Studies

Nicholas Nissen, MD: Treatment Selection

Nicholas Nissen, MD
Published Online:Jun 18, 2015
Dale P is a 61-year-old Jamaican-American male from Houston, Texas, with a history of HCV infection and cirrhosis, who works in corporate cell-phone sales.

Unresectable Hepatocellular Carcinoma: case 3

Inguinal lymph node biopsy should be undertaken to prove the presence of metastatic disease. Local control could be attempted with regional therapy. Systemic therapy should be considered. Rare oligometastatic disease can be resected with good outcomes as well.

CASE 3: Unresectable Hepatocellular Carcinoma

Dale P is a 61-year-old Jamaican-American male from Houston, Texas, with a history of HCV infection and cirrhosis, who works in corporate cell-phone sales.

In February of 2012 the patient presented with upper right quadrant discomfort; CT scan showed the presence of a 4.1 × 3.9-cm mass consistent with HCC in the setting of cirrhosis; he was referred to the multidisciplinary team for further assessment.
  • Initial assessment showed a MELD score of 7 and Child Pugh A class
  • The patient was not considered appropriate for transplant based on prior history of successfully treated renal cancer (4 years prior) and patient declining to pursue a transplant evaluation
  • Medical history notable for heavy alcohol use and substance abuse approximately 30 years ago, stroke in mother, deep vein thrombosis in father
  • Other medical history included nonresponse to pegylated interferon and ribavirin for HCV 5 years earlier; current medications included antihypertensives and aspirin
  • Patient recommended for liver resection in April 2012
  • He underwent R0 resection. Pathology showed moderately differentiated HCC with negative margins and no evidence of microvascular invasion
  • On follow up in April 2013, patient shows no evidence of disease recurrence on MR which is performed every 3 months
On follow up in August of 2014, ~2 years post resection, there is imaging evidence of recurrence and metastasis.
  • MRI detects multiple lesions at the postsurgical site, largest ~1.7 cm, and a nodule in the inguinal lymph node, ~1.9 x 1.0 cm
  • Patient’s current assessment shows a MELD score of 9 and Child Pugh A
Publications
Copyright © TargetedOnc 2017 Intellisphere, LLC. All Rights Reserved.