ONCAlert | 2018 SGO Annual Meeting on Women’s Cancer
Multiple Myeloma Case Studies

Case Studies: IMiD Sequencing in Relapsed Myeloma with Keith Stewart, MB, ChB

Keith Stewart, MB, ChB, reviews the goals of therapy and IMid sequencing in multiple myeloma using case-based scenarios.

IMiD Sequencing in Relapsed Myeloma with Keith Stewart, MB, ChB Case 1

Case Scenario 1:

July 2011

  • The patient is a 61-year-old Caucasian female who was diagnosed with stage II MM. Genetic testing showed her to have t(4:16). At the time she was treated with lenalidomide, bortezomib, and dexamethasone (RVD) induction therapy followed by autologous stem cell transplantation.
  • She achieved a partial response with RVD and remained in remission. Based on her high-risk cytogenetics, the patient was placed on lenalidomide maintenance therapy.

August 2016

  • Routine follow up shows that her M-protein levels have now risen to 1.4 g/dL and her light chain levels continue to rise.
  • Although she has developed mild anemia and her creatinine level is slightly elevated to 1.3 mg/dL, she continues to work full-time, has no bone pain, and a has a normal calcium level.   
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