ONCAlert | 2018 Gastrointestinal Cancers Symposium

Results and Key Takeaways from the Final OS Analysis of the CLEOPATRA Study

Sandra M. Swain, MD
Published Online: 12:12 PM, Thu October 2, 2014
Sandra M. Swain, MD, Medical Director of the Washington Cancer Institute at MedStar Washington Hospital Center, discusses results and key takeaways from the final overall survival (OS) analysis of the CLEOPATRA study. This study looked at first-line pertuzumab, trastuzumab, and docetaxel for the treatment of patients with HER2-positive metastatic breast cancer.

Clinical Pearls

  • Median OS was 40.8 months in the placebo arm and 56.5 months in the pertuzumab arm – a different of 15.7 months.
  • The standard first line treatment for patients with HER2-positive metastatic breast cancer should be pertuzumab, trastuzumab, and a taxane.
  • In practice, community oncologists could use paclitaxel instead of docetaxel.

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