Recurrent HR+ Breast Cancer

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Recurrent HR+ Breast Cancer

A 58-Year-Old Woman With Recurrent HR+ Breast Cancer

December 2013

  • A 58-year-old postmenopausal woman was referred for further evaluation of a suspicious left-sided lesion found incidentally on routine mammogram
    • MRI revealed a 4.3-cm lesion in her left breast
    • PMH unremarkable
  • She underwent lumpectomy with axillary staging
  • Biopsy findings:
    • Histology: lobular carcinoma, grade 2
    • Hormone receptor status: ER+/ PR (-)
    • HER2,IHC 1+
    • OncotypeDx RS, 19
  • Staging, T2N0M0
  • ECOG 0
  • She was started on adjuvant anastrozole

September 2018

  • On routine follow-up, the patient reports increasing fatigue and intermittent bouts of abdominal pain with nausea
  • CT with contrast showed several small lesions in the liver; biopsy confirmed metastatic disease.
    • The patient was started on ribociclib; anastrozole was changed to fulvestrant
    • Imaging at 3 and 6 months showed a partial response
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John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
John Mascarenhas, MD, an expert on myelofibrosis
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