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Breast Cancer Case Studies

Case Studies: HER2+ Early-Stage Breast Cancer: Perioperative Approaches

Denise A. Yardley, MD, reviews the case of a 56-year-old woman who presents with early-stage HER2+ breast cancer.

HER2+ Early-Stage Breast Cancer: Perioperative Approaches

A 56-Year-Old Woman Receiving Adjuvant Therapy for HER2+ Breast Cancer

  • A 56-year-old postmenopausal woman was referred for evaluation of a left-sided spiculated mass (2.4-cm) with scattered microcalcifications, found incidentally on screening mammography. Mammogram 12 months earlier was normal.
  • Ultrasound confirmed a hypoechoic mass of approximately 2.4 cm X 2,3 cm by 1.8 cm at the 2 o’clock position in the left breast, 4 cm from the nipple. Axillary ultrasound demonstrated 3 enlarged lymph nodes with cortex thickening.
  • Core biopsy of the breast mass revealed poorly differentiated invasive ductal carcinoma, ER/PR-negative, HER2 IHC 3+; lymph node sampling revealed the presence of breast cancer.
  • Staging: T2N1M0
  • She received neoadjuvant docetaxel and carboplatin with concurrent trastuzumab and pertuzumab.
  • Surgical resection scattered microscopic foci of residual disease spanning 4 mm; no involved lymph nodes
    • Re-staging, ypT1aypN0M0
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