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Chronic Lymphocytic Leukemia Case Studies

Case Studies: High-Risk IgVH-Unmutated Chronic Lymphocytic Leukemia

Ian W. Flinn, MD, PhD, reviews the case of a patient with newly diagnosed symptomatic chronic lymphocytic leukemia, and high-risk cytogenetic risk factors.

High-Risk IgVH-Unmutated Chronic Lymphocytic Leukemia

Case:  A 62-Year–Old Male With IgVH-Unmutated CLL

  • A 62-year-old male presented to PCP with complaints of extreme fatigue and night sweats
  • PE: Enlarged mobile lymph nodes bilaterally (~1.5 cm), no palpable spleen or liver
  • Laboratory findings:
    • WBC; 100 X 109/L
    • Lymphocytes; 82 X 109/L
    • Hb; 11.2 g/dL
    • Platelets; 190 X 109/L
    • ANC; 1,950/mm3
    • LDH 150 U/L
  • Cytogenetic; del(11q), IgVH-unmutated
  • β2M, 2.9 mg/L
  • Referred to community oncology who diagnosed patient with chronic lymphocytic leukemia
  • Patient was started on ibrutinib + rituximab (IR)
  • Rai Stage I
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