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Lung Cancer Case Studies

Case Studies: Metastatic Lung Cancer with Jared M. Weiss, MD

Jared Weiss, MD, discusses the role of molecular testing in advanced lung cancer, particularly for newly diagnosed EGFR-positive non–small cell lung cancer.

Metastatic Lung Cancer with Jared M. Weiss, MD: Case 1

Weiss case 1:

A 65-year-old man with stage IV NSCLC.

  • Tissue biopsy showed EGFR+ adenocarcinoma
  • The patient was enrolled in a clinical trial of erlotinib vs erlotinib/bevacizumab
  • He was treated with erlotinib for 10 months before developing asymptomatic progression, with slowly growing lesions.
  • He was continued on erlotinib for 3 more months; His next scan showed rapid progression.
  • Repeat bronchoscopy and mutation testing showed an acquired EGFR T790M mutation
  • Patient was subsequently switched to osimertinib
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