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Lung Cancer Case Studies

Case Studies: Metastatic Lung Cancer with Jared M. Weiss, MD

Jared Weiss, MD, discusses the role of molecular testing in advanced lung cancer, particularly for newly diagnosed EGFR-positive non–small cell lung cancer.

Metastatic Lung Cancer with Jared M. Weiss, MD: Case 2

Weiss case 2:

A 62 year-old neversmoker with stage IV adenocarcinoma

  • Mutation testing showed an EGFR exon 19 mutation
  • The patient was treated with erlotinib for 1 year; he developed diarrhea and rash which was successfully managed
  • After 3 months, his disease showed progression on CT; he remained without symptoms.
  • He subsequently developed cough and shortness of breath, correlated to progression of a centrally located lung lesion on his follow up CT scan
  • Repeat biopsy and molecular testing of the central lesion showed EGFR T790M-positivity
  • He was switched to osimertinib therapy and achieved a partial response
  • The patient reported dramatic improvement in his well-being
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