Case Studies: EGFR+ NSCLC
Mark Socinski, MD, outlines the diagnosis and treatment of a 66-year-old Asian woman who presents with EGFR+ non–small cell lung cancer.
EGFR+ NSCLC
EGFR+ NSCLC
December 2017
- A 66-year-old Asian woman presents to her PCP complaining of visual disturbances, nausea, fatigue, and sporadic headaches
- History: HTN, managed on candesartan; hyperlipidemia managed on simvastatin; no smoking history
- PE: BP, 148/70; LLL auscultation reveals decreased breath sounds
- CBC: WNL
- Imaging studies:
- MRI of the head demonstrated a right parietal mass at the gray–white junction with vasogenic edema
- CT of chest, abdomen, and pelvis revealed a 3.4-cm mass in the left lower lobe, and several small liver nodules
- CT-guided transthoracic needle biopsy of the lung lesion showed grade 2 adenocarcinoma, acinar
- Molecular testing: EGFR exon 19 deletion
- Staging: T2aN0M1c
- ECOG 1
- The patient was started on osimertinib 80 mg once daily
