Treatment Considerations for Unresectable Locally Advanced NSCLC
Treatment Considerations for Unresectable Locally Advanced NSCLC
- A 64-year-old man presented with shortness of breath and persistent cough of 18 months’ duration; recently, he has experienced chest pain, fatigue, and blood in his sputum. After consulting with his primary care physician, he was referred for oncology evaluation
- Patient history includes
- Current smoker (1/2 pack day)
- Hypertension
- Acute MI at age 60
- Evaluation and follow up testing reveal
- Non-small cell lung cancer in left lung and 2 lymph nodes (Stage IIIa)
- WHO performance status: 1
- Histology: adenocarcinoma
- EFGR, BRAF,andALK/ROS1mutation status: wild-type
- PD-L1 status: ≥25%
- He underwent multidisciplinary evaluation and was not a candidate for surgery; he was treated with chemoradiotherapy:
- Concurrent carboplatin-paclitaxel doublet chemotherapy and radiotherapy (60 Gy)
- Achieved partial response
- He had no disease progression 20 days after his last radiotherapy treatment, and began treatment with durvalumab
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