ONCAlert | 2018 ASCO Annual Meeting
Melanoma Case Studies

Case Studies: Treatment of Malignant Melanoma

In this case-based interview, Jason Luke, MD, FACP, provides an overview on the therapeutic management for a patient who presents with signs of metastatic melanoma.

Treatment of Malignant Melanoma

  • A 46-year-old Caucasian female presented one year ago with deep ulcerated primary tumor and multiple involved lymph nodes.
  • She was diagnosed with stage IIIC melanoma.
  • Patient underwent wide local incision and compete lymph node dissection and appeared to be clear of disease.
  • Patient decided not to pursue adjuvant therapy after surgery.
  • Six months after surgery, she developed abdominal pain.
  • Imaging showed multiple masses in the liver, > 1 cm, scattered pulmonary nodules and some enlarged lymph nodes.
  • Tumor biopsy confirmed melanoma and mutational analysis showed BRAF V600E mutation.
  • The patient is started on dabrafenib 150 mg bid and trametinib 2 mg qd.
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