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Multiple Myeloma Case Studies

Case Studies: Biochemical Progression of Stage II High-Risk Multiple Myeloma

In this case-based interview series, Ajai Chari, MD, discusses the case of a woman who is diagnosed with stage II multiple myeloma with high-risk cytogenetics. He explains her treatment approach and supporting data at diagnosis and after disease progression.

Biochemical Progression of Stage II High-Risk Multiple Myeloma

Biochemical Progression of Stage II Myeloma

July 2011

  • A 61-year-old Caucasian female was diagnosed with stage II multiple myeloma
  • Genetic testing showed t(14:16)
  • At the time she was treated with lenalidomide, bortezomib, and dexamethasone (RVD) induction therapy followed by autologous stem cell transplantation
  • She achieved a near complete remission with RVD and transplant
  • Based on her high-risk cytogenetics, the patient was placed on lenalidomide maintenance therapy

August 2016

  • On routine follow up, the patient reports having mild fatigue but continues to work full-time; she has grade 1 neuropathy
    • M-protein, 1.3 g/dL
    • SFLC, kappa, 150 mg/L
    • Hb, 10.3 g/dL
    • Creatinine, 1.3 mg/dL
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