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Multiple Myeloma Case Studies

Case Studies: Treatments for Relapsed and Refractory Multiple Myeloma

Ravi Vij, MD, describes the case of a 72-year-old male diagnosed with multiple myeloma, and his subsequent relapse 2 years later.

Treatments for Relapsed and Refractory Multiple Myeloma

CASE: A 72-year-old Caucasian Man With Relapsed Multiple Myeloma 

September 2016

  • Patient history: At the age of 72, a Caucasian man was diagnosed with multiple myeloma; R-ISS stage I
  • Other relevant history includes hypertension and difficulty walking up stairs
  • He was treated with lenalidomide/dexamethasone and achieved a VGPR
  • Treatment duration was 9 months; patient subsequently discontinued therapy 12 months ago

June 2018

  • On routine follow-up, patient complains of increasing problems with fatigue, and has rising levels of M protein
  • Laboratory results:
    • Hb, 9.6 g/dL
    • Ca2+ 9.2 mg/dL
    • Creatinine, 0.8 mg/dL
    • M-protein, 3.0 g/dL
    • 30% plasma cells in bone marrow
  • Cytogenetics/FISH: del(17p)
  • ECOG PS: 2
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