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Multiple Myeloma Case Studies

Case Studies: Relapsed/Refractory Multiple Myeloma

Relapsed/Refractory Multiple Myeloma

Case:  75-Year-Old Man With Symptomatic R/R Multiple Myeloma

January 2015

  • A 75-year-old man was diagnosed with multiple myeloma; R-ISS stage I
  • PMH: hypertension; coronary artery disease post stent placement
  • Patient was treated with lenalidomide + dexamethasone for 9 months; transplant-ineligible due to age and performance status
  • Patient achieved a VGPR, discontinued treatment thereafter due to patient request

September 2018

  • On routine follow-up 3 years later, patient presents with new-onset back pain and generalized fatigue
  • Imaging: multiple new lytic lesions with compression fractures
  • Laboratory results:
    • Hb, 10.7 g/dL
    • Ca2+, 9.3 mg/dL
    • Creatinine, 1.1 mg/dL
    • M-protein, 3.2 g/dL
  • Cytogenetics/FISH: del (17p) discovered at relapse
  • ECOG PS: 2
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