Case: 75-Year-Old Man With Symptomatic R/R Multiple Myeloma
January 2015
- A 75-year-old man was diagnosed with multiple myeloma; R-ISS stage I
- PMH: hypertension; coronary artery disease post stent placement
- Patient was treated with lenalidomide + dexamethasone for 9 months; transplant-ineligible due to age and performance status
- Patient achieved a VGPR, discontinued treatment thereafter due to patient request
September 2018
- On routine follow-up 3 years later, patient presents with new-onset back pain and generalized fatigue
- Imaging: multiple new lytic lesions with compression fractures
- Laboratory results:
- Hb, 10.7 g/dL
- Ca2+, 9.3 mg/dL
- Creatinine, 1.1 mg/dL
- M-protein, 3.2 g/dL
- Cytogenetics/FISH: del (17p) discovered at relapse
- ECOG PS: 2