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Myeloproliferative Neoplasms Case Studies

Case Studies: A 58-Year-Old Woman with Polycythemia Vera

Prithviraj Bose, MD, discusses the diagnostic work up, treatment, and adverse-event management of polycythemia vera, with special consideration for the role of ruxolitinib.

A 58-Year-Old Woman with Polycythemia Vera

Case: 58-Year-Old Woman Diagnosed With Polycythemia Vera

November 2018

  • A 58-year old woman presents to PCP complaining of abdominal pain, dizziness and headaches
  • PE: BP 140/85; Splenomegaly ~6 cm below left costal margin
  • PMH: No prior history of thrombosis
  • Lab values:
    • HGB:  17.1 g/dL
    • Hct: .50 L/L
    • RBC: 71 x 1012/L
    • WBC:  13.2 x 109/L
    • Serum EPO: 4.1 mU/mL
  • Bone Marrow Biopsy: Erythroid hyperplasia
  • Cytogenetics: JAK-V617F mutation
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