Primary Myelofibrosis

Video

Primary Myelofibrosis

Case: 72-Year-Old Man Diagnosed With Primary Myelofibrosis

December 2018

  • A 72-year old man presents to primary care physician with complaints of fatigue, headache, night sweats, poor appetite, and 10-15lb weight loss over past few months; report of increased abdominal pain over the last 3 months
  • PMH: mild hypertension
  • PE: BP 130/85; Splenomegaly ~14 cm below left costal margin
  • Lab values:
    • HGB: 8.9 g/dL
    • Platelets: 189 x 109/L
    • WBC: 27.2 x 109/L
    • Serum LDH: 1500 U/L
    • Serum EPO: 11.5 mU/mL
  • Bone Marrow Biopsy:
    • MF-2
    • Circulating blasts, 1.2%
    • JAK-V617F mutation, del(20q)
  • Diagnosis: Primary myelofibrosis
Related Videos
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Stephen T. Oh, MD, PhD, an expert on myelofibrosis
Related Content