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Myeloproliferative Neoplasms Case Studies

Case Studies: Diagnosis and Treatment of Myelofibrosis

In this case-based interview, Jamile Shammo, MD, presents a case of a 72-year-old male who is diagnosed with primary myelofibrosis and the treatment approach for this type of patient.

Diagnosis and Treatment of Myelofibrosis

June 2016

  • A 72-year old male presents to his primary care physician with fatigue, abdominal pain lasting 3 months, and night sweats
  • PMH includes depression and gout
  • Physical Exam: BP, 155/85; spleen palpable 6 cm below costal margin
  • Laboratory values:
    • Hb= 9.8 g/L
    • HCT= 38%
    • WBC= 22.3 x109/L
    • Platelets= 255 x109/L
  • Bone marrow biopsy:
    • Megakaryocytic proliferation and atypia with evidence of reticulin fibrosis
  • Blood smear showed leukoerythroblastosis
  • Genetic testing shows JAK2 V617F mutation
  • Diagnosis: Primary myelofibrosis
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