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Socinski Braf Mutated Nsclc Case Studies

Case Studies: Treatment of BRAF Mutated Non-Small Cell Lung Cancer

In this case-based interview, Mark A. Socinski, MD, provides an overview on the treatment of a patient who develops BRAF-mutated non–small cell lung cancer.

Treatment of BRAF Mutated Non-Small Cell Lung Cancer

  • 67-year-old female, former smoker (30 pack-years, quit 10 years ago) presented to her pulmonologist with increased cough, dyspnea and hemoptysis.
  • Past medical history of mild COPD.
  • Patient swims three times a week and is continuing normal activities.
  • ECOG PS was assessed as 1.
  • CT scan of chest and abdomen show a lower right lobe lung nodule with several small liver lesions.
  • PET/CT scan indicated lung cancer with liver metastases.
  • Core needle biopsy was performed in the liver. Pathology report showed adenocarcinoma consistent with non-small cell lung cancer (NSCLC).
  • Mutation testing showed a BRAF V600E mutation.
  • PD-L1 status was negative.
  • Patient was started on pemetrexed and carboplatin.
  • After 3 of 6 planned cycles patient showed worsening signs of dyspnea with a weight loss of 10%.
  • Repeat CT scan showed progression of primary lesion.
  • Patient was started on dabrafenib + trametinib.
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