Breast Cancer Symposium

Combinations With CDK 4/6, PI3K Inhibitors Show Activity in Breast Cancer

September 12, 2014

The combination of letrozole with either the CDK4/6 inhibitor LEE011 or the PI3 kinase Inhibitor BYL719 demonstrated clinical activity for women with ER-positive, HER2-negative breast cancer.

Veliparib Demonstrates Clinical Activity in Patients with BRCA-Positive Breast, Ovarian Tumors

September 06, 2014

The poly (ADP-ribose) polymerase (PARP) inhibitor veliparib exhibits antitumor activity and is safe and tolerable on a continuous dosing schedule when used for the treatment of patients with BRCA-positive and BRCA-wild type tumors.

Trastuzumab May Enhance Durability of Response to Fulvestrant

September 06, 2014

HER2 blockade may enhance the duration of response to fulvestrant, according to researchers from the University of Cincinnati College of Medicine.

HER2-Derived Peptide Vaccine Cuts Recurrence in High-Risk Breast Cancer

September 06, 2014

A novel HER2-derived peptide (GP2) vaccine designed to stimulate CD8+ cytotoxic T-lymphocytes reduced the rate of breast cancer recurrence and proved safe and well tolerated in an adjuvant setting.

The Impact of Breast Cancer Diagnosis on Sexual Dysfunction

September 06, 2014

Hadeel Assad, MD, hematology/oncology fellow, Providence Hospital and Medical Center, discusses an analysis of the impact of breast cancer diagnosis on sexual dysfunction.

Obesity and Menopausal Status in Breast Cancer

September 06, 2014

Clifford A. Hudis, MD, discusses obesity and menopausal status as determinants of procarcinogenic breast inflammation.

LH-RH Analog as Adjuvant to Chemotherapy May Preserve Fertility in Younger Breast Cancer Patients

September 05, 2014

Long-term follow-up of a phase III clinical trial shows strong trends toward a greater likelihood of resuming menses and becoming pregnant when a luteinizing hormone-releasing hormone (LH-RH) analog is administered with chemotherapy in patients with breast cancer.

Understanding Tumor Biology Informs Treatment Choice in Early Breast Cancer

September 05, 2014

Breast conserving therapy (BCT) improves overall survival compared with other local treatments in patients with stage I breast cancer, according to an examination of the National Cancer Database (NCDB).

Decision Making and Patient Preferences Prior to Surgery

September 05, 2014

Katharine Yao, MD, gives an overview of an analysis that looked at patient preferences prior to surgery.

Evolving Standards of HER2-Positive Breast Cancer

September 05, 2014

Sunil Verma, MD, MSEd, FRCPC, discusses evolving standards of early stage HER2-positive breast cancer.