ONCAlert | Upfront Therapy for mRCC

Thyroid Hormone Receptor and Runx2 Expression in Thyroid Cancer Cells

Frances Carr, PhD
Published Online: 9:40 PM, Sat March 7, 2015
Frances Carr, PhD, professor, Department of Pharmacology, The University of Vermont, discusses the relationship between the thyroid hormone receptor and Runx2 expression in thyroid cancer cells.


  • The thyroid hormone receptor is a possible tumor suppressor.
  • Studies have shown that Runx2 may be a tumor promoter in papillary thyroid cancer.
  • An inverse relationship was seen between thyroid hormone receptor expression and Runx2.
  • This relationship is being explored and could have therapeutic implications in the future.

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