Navigating Treatment Choices in Urothelial Cancer
December 15th 2023Guru P. Sonpavde, MD, provides insights on the phase 3 CheckMate 901 trial and explains what a community oncologist should know about the use of concurrent frontline nivolumab plus chemotherapy in metastatic or unresectable urothelial carcinoma based on this study.
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Vibostolimab/Pembrolizumab Fails to Reach Statistical Significance in NSCLC
December 8th 2023The combination of vibostolimab and pembrolizumab plus docetaxel did not significantly improve progression-free survival compared with docetaxel monotherapy in patients with previously treated metastatic non–small cell lung cancer.
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Results From THOR Study of Erdafitinib in FGFR-Altered Urothelial Cancer
November 7th 2023Arlene O. Siefker-Radtke, MD, discusses the results of the phase 3 THOR study of erdafitinib vs pembrolizumab in pretreated patients with advanced or metastatic urothelial cancer with select FGFR alterations.
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Tisotumab Vedotin Shows Potential in Cervical Cancer With Disease Progression
October 27th 2023In an interview with Targeted Oncology, Brian Slomovitz, MD, details findings from the innovaTV 301 trial investigating tisotumab vedotin for the treatment of recurrent or metastatic cervical cancer.
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First-line Treatment of VR-CAP Regimen Shows Efficacy in Marginal Zone Lymphoma
October 23rd 2023In a phase 2 study, frontline bortezomib, rituximab, cyclophosphamide, doxorubicin hydrochloride, prednisone, and cytarabine hydrochloride was well tolerated in patients with B-cell non-Hodgkin marginal zone lymphoma.
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First-Line Amivantamab Plus Lazertinib Represents New SOC in Advanced EGFR+ NSCLC
October 23rd 2023Amivantamab-vmjw with lazertinib showed positive survival results vs osimertinib as frontline therapy for patients with advanced non–small cell lung cancer harboring classical EGFR sensitizing mutations.
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Lenvatinib/Pembrolizumab Plus Chemotherapy Shows Manageable Toxicity in mESCC
October 23rd 2023The safety run-in of the LEAP-014 trial showed acceptable toxicity and antitumor responses in patients with metastatic esophageal cancer receiving pembrolizumab, lenvatinib, and chemotherapy consisting of cisplatin plus either paclitaxel or 5-fluororacil.
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Continued Benefit Shown With Pembrolizumab, Lenvatinib in Endometrial Cancer
October 23rd 2023An exploratory analysis of Study 309/KEYNOTE-775 showed further benefit for patients and consistent safety in patients who received pembrolizumab plus lenvatinib for advanced endometrial cancer who continued lenvatinib treatment.
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Dato-DXd Induces Significantly Improved PFS in HR+, HER2- Metastatic Breast Cancer
October 23rd 2023Treatment with datopotamab deruxtecan led to a statistically significant and clinically meaningful improvement in progression-free survival in patients with metastatic hormone receptor-positive breast cancer.
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Three of 4 Molecular Subgroups Respond to Dostarlimab in Advanced Endometrial Carcinoma
October 23rd 2023Findings from the ENGOT-EN6-NSGO/GOG-3031/RUBY trial showed that patients with dMMR/MSI-H had a progression-free survival rate of 57.0% in the dostarlimab arm vs 10.2% in the placebo arm.
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PFS Improvement Seen With Cabozantinib in Previously Treated Advanced Neuroendocrine Tumors
October 23rd 2023At a median follow-up of 13.9 months, patients with extra-pancreatic NETs treated with cabozantinib experienced a median progression-free survival of 8.3 months vs 3.2 months with placebo.
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