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ONCAlert | Upfront Therapy for mRCC

Combining Dalantercept and Axitinib for Advanced Kidney Cancer

Martin H. Voss, MD
Published Online: 6:04 PM, Mon March 2, 2015
Martin H. Voss, MD, medical oncologist, Memorial Sloan Kettering Cancer Center, discusses the phase I/II DART study. The study compared dalantercept plus axitinib with placebo plus axitinib for patients with advanced clear cell renal cell carcinoma.

Clinical Pearls

  • Dose-determining toxicities for dalantercept were fluid retention and anemia.
  • No additive toxicity was observed. The combination was well tolerated, even at the highest dose levels.
  • Median PFS was approximately 8 months for the entire study population.
  • Median PFS has not yet been reached among patients receiving the dose chosen for part II of the study.


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