ONCAlert | Upfront Therapy for mRCC

OS Increases With Checkpoint Inhibitor Doublet in Advanced Colorectal Cancer

Wayne Kuznar
Published Online: 2:51 AM, Mon January 21, 2019
Eric X. Chen, MD
Eric X. Chen, MD
When durvalumab (Imfinzi) and tremelimumab were combined with best supportive care, the combination reduced the risk of progression or death by 28% compared with best supportive care alone, according to findings from a phase II clinical trial. 

Results from the randomized Canadian Cancer Clinical Trials Group (CCCTG) CO.26 trial presented at the 2019 Gastrointestinal Cancers Symposium demonstrated that the addition of the immune checkpoint doublet to best supportive care demonstrated a median overall survival (OS) of 6.6 months compared with 4.1 months with supportive care alone (hazard ratio [HR], 0.72; 90% CI, 0.54-0.97; P = .07). However, median progression-free survival (PFS) did not significantly differ between arms (1.8 months vs. 1.9 months; HR, 1.01; 90% CI, 0.76-1.34; P = .97).

“CCCTG study is the first study demonstrating the effectiveness of immune checkpoint blockade in [patients with] colorectal cancer unselected for mismatch repair deficiency,” said Eric X. Chen, MD, PhD, affiliate scientist, Princess Margaret Cancer Centre, Toronto.

Previously, treatment with immune checkpoint blockade therapy had not proven to be effective in refractory colorectal cancer except in patients with mismatch repair deficiency, Chen explained. However, the researchers hoped that targeting both PD-L1 with durvalumab and CTLA-4 with tremelimumab would have additive and/or synergistic activity as their mechanisms are nonredundant. In addition, a previous phase Ib study showed that the 2 agents could be combined safely.

A total of 180 patients with advanced refractory colorectal cancer and an ECOG performance status of 0 or 1 were randomized 2:1 to durvalumab plus tremelimumab with best supportive care or best supportive care alone. Eligibility criteria included patients with measurable disease for which all available standard regimens, such as bevacizumab (Avastin) and regorafenib (Stivarga), had failed, meaning that an EGFR inhibitor must have been used if the patient had RAS wild-type disease. No prior therapy with PD-1/PD-L1 or CTLA-4 inhibitors was permitted.

Both arms received at least 1 prior systemic therapy, including 155 patients who had prior VEGF-targeting therapy, and 65 who had prior radiotherapy. All patients with RAS wild-type colorectal cancer in the active treatment arm and 83% in the control arm were previously treated with cetuximab (Erbitux) or panitumumab (Vectibix).

The 119 patients randomized to the doublet regimen received 1,500 mg of durvalumab intravenously on day 1 of every 28-day cycle and 75 mg of tremelimimab intravenously on day 1 for the first 4 cycles.

OS served as the primary endpoint, while secondary endpoints included PFS, safety and toxicity, and objective response rate (ORR).

After a median follow-up of 15.2 months, the unstratified HR for OS was 0.72 in favor of durvalumab and tremelimumab (90% CI, 0.54-0.97) with a P value of .07 (a 2-sided P value < .10 was considered statistically significant for this analysis). The unadjusted HR for OS was .70 (P = .03) also favoring active treatment.

All subgroups evaluated in the study also demonstrated superior OS with the doublet regimen, including those by primary tumor location and BRAF and RAS (KRAS, NRAS) status. In the 166 patients with microsatelite stable disease, the HR for OS was 0.66 (90% CI, .49-.89; = .024) in favor of active treatment.

At baseline in the active treatment arm and the best supportive care arm, median patient age was 65 years and 64 years, respectively. In addition, 62% and 77%, respectively, were male, and liver metastases were present in 67% and 77% of patients. ECOG performance status was 1 in 72% of patients in both arms. The primary site of disease was left colon plus rectum in the doublet arm (73%) and the control arm (67%). The majority of patients in the active treatment arm and the control group had KRAS mutations (78% vs 49%, respectively), NRAS mutations (2% vs 16%), and BRAF V600E mutations (7% vs 11%).

Overall, 169 patients had baseline blood samples available for molecular analysis, and 168 had successful circulating tumor DNA assessment based on baseline blood. Sequencing was performed using a 500-gene panel with 93.7% sensitivity and 99.2% specificity for detecting microsatellite instability. One patient in each arm had microsatellite instability-high/mismatch repair-deficient tumors.

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