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Ancestral Progenitors in Glioblastoma Tumor Recurrence

Roeland GW Verhaak, PhD
Published Online: 4:59 PM, Wed November 19, 2014
Roeland GW Verhaak, PhD, assistant professor, Department of Bioinformatics and Computational Biology, Division of Quantitative Sciences, The University of Texas MD Anderson Cancer Center, discusses a study that examined the alteration of the p53 pathway and ancestral progenitors to determine if they were associated with tumor recurrence in glioblastoma.

Clinical Pearls:
  • This study compared the primary tumor sample and the recurrent tumor sample from the same patient in 23 patients.
  • The whole genome sequencing dataset, which included 10 patients, identified sets of tumor cells that may explain why the recurrent tumor cell is chemo resistant.
  • In 2 out of the 10 patients in the dataset, the tumor recurrence was initiated by an ancestral tumor cell.
  • In 4 of the 10 patients, researchers saw clonal evolution.

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