Experts review 3 clinical cases, discuss treatment options and relevant clinical trials in GIST.
EP. 1: Case 1: 66-Year-Old Woman With GIST
The experts discuss a case presentation of a 66-year-old woman with heavily pretreated GIST, and comment on follow-up times and treatment options.
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EP. 2: Case 1: Molecular Testing in GIST
Experts discuss the considerations of lines of therapy, comment on molecular testing, and the role of repeat biopsies.
EP. 3: Case 1: Treatment Considerations in GIST
Third-line treatment recommendations for patients with GIST and a discussion on side effect management.
EP. 4: Case 1: INVICTUS Trial
The panelists discuss the phase 3 INVICTUS trial of ripretinib and the phase 1 study of ripretinib intra-patient dose escalation.
EP. 5: Case 2: KIT Exon 9-Mutated GIST
The experts present and discuss a case of a patient with KIT exon 9-mutated GIST, an including an overview of surgical options.
EP. 6: Case 2: The Role of Imatinib in GIST
The experts discuss the use of imatinib in patients with KIT exon 9-mutated GIST. Additionally, they comment on surgical options for patients with GIST.
EP. 7: Case 2: Treatment Options in Exon 9–Mutated GIST
Key opinion leaders consider later lines of therapy in metastatic KIT exon 9–mutated GIST and how to monitor and mitigate toxicities.
EP. 8: Case 2: VOYAGER and INTRIGUE Trials
A panel of experts review the VOYAGER and INTRIGUE trials.
EP. 9: Case 3: PDGFRα D842V-Mutated GIST
Presentation and considerations for a case of PDGFRα D842V-mutated GIST.
EP. 10: Case 3: The NAVIGATOR Trial
Experts discuss KIT and PDGFRα D842V-mutations in GIST and present the NAVIGATOR trial.
EP. 11: Case 3: The Role of Avapritinib in GIST
The panel discuss the use of avapritinib in GIST, including doses, toxicities, and secondary resistance to treatment.
EP. 12: Case 3: Take Home Messages in Treating GIST
The experts comment on take-home messages, and what they hope to see in the future in treating GIST.
