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Initial Results from the CALGB 10801 Study

Timothy S. Pardee, MD
Published Online:7:59 PM, Wed May 14, 2014
Timothy S. Pardee, MD, Assistant Professor, Hematology & Oncology, Wake Forest University Baptist Medical Center, describes initial results of the CALGB 10801 (Alliance) study, which added dasatinib to standard induction and consolidation therapy for newly diagnosed patients with core binding factor (CBF) acute myeloid leukemia (AML).

Clinical Pearls:
  • This study looked at improving the outcomes of AML patients who have translocation between chromosomes 8 and 21 or an inversion of chromosome 16
  • These patients generally do better than other AML patients, but their outcome is still worse compared to other hematologic malignancies
  • The study added dasatinib, which has activity against c-Kit, in the hopes of improving survival
  • Results found that dasatinib was a tolerable regimen and demonstrated reasonable and encouraging response rates
  • This data is preliminary and more mature results are needed before conclusions are drawn
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