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Dr. Jose P. Zevallos on Tobacco-Related Mutations in HPV-Positive Oropharyngeal SCC

Jose P. Zevallos, MD, MPH, FACS
Published Online:11:52 PM, Thu March 3, 2016

Jose P. Zevallos, MD, MPH, FACS, assistant professor, director of Oncologic Research, University of North Carolina School of Medicine, discusses a recent study that looked at molecular profiles determined by targeted DNA sequencing of patients with HPV-positive oropharyngeal squamous cell carcinoma (SCC). The purpose of the study was to determine if patients with HPV-positive oropharyngeal SCC, who were also smokers, had a different mutational status than non-smokers.

Zevallos says the study consisted of 66 patients and found that there were distinct genomic differences between HPV-positive smokers and non-smokers. He adds that the mutations found in smokers with HPV-positive oropharyngeal SCC mimic the mutations of non-smokers with HPV-negative oropharyngeal SCC.
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