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Overcoming Resistance to Venetoclax in AML

Sangmin Lee, MD
Published Online:4:56 PM, Mon March 4, 2019

Sangmin Lee, MD, a physician at Weill Cornell Medicine, discusses a potential way to overcome venetoclax (Venclexta) resistance in acute myeloid leukemia (AML).

Lee says that one challenge with AML is that patients still relapse and become refractory to treatments such as venetoclax. However, resistance to venetoclax has been associated with high expression of MCL-1. Compounds targeting MCL-1 seem to be promising in this treatment landscape.
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