Treating High-Risk Multiple Myeloma
Treating High-Risk Multiple Myeloma
- A 74-year-old woman was admitted to the ICU with pneumococcal bacteremia. She complained of recent severe fatigue, loss of appetite, nausea
- History: chronic HTN, aortic insufficiency, diabetes mellitus
- X-ray of the pelvis showed numerous lytic lesions in the ilium and a large lesion in the right proximal femur
- MRI confirmed a 9-mm lesion in the right femoral head and numerous bilateral T1 hypointense and T2 hyperintense lesions in both iliac region
- Laboratory results:
- Hb, 8.3 g/dL
- Ca2+16.35 mg/dL
- Creatinine, 1.0 mg/dL
- Creatinine clearance, 59 mL/min
- M-protein, 1.6 g/dL
- B2M, 4.9 mcg/mL
- SFLC, kappa, 150 mg/L
- Bone marrow biopsy, 70% plasma cells
- Molecular testing, t(4;14)
- ECOG 2
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