September 22, 2016


Weiss case 1:

A 65-year-old man with stage IV NSCLC.

  • Tissue biopsy showed EGFR+ adenocarcinoma
  • The patient was enrolled in a clinical trial of erlotinib vs erlotinib/bevacizumab
  • He was treated with erlotinib for 10 months before developing asymptomatic progression, with slowly growing lesions.
  • He was continued on erlotinib for 3 more months; His next scan showed rapid progression.
  • Repeat bronchoscopy and mutation testing showed an acquired EGFR T790M mutation
  • Patient was subsequently switched to osimertinib