ONCAlert | 2017 San Antonio Breast Cancer Symposium
Breast Cancer Case Studies

Case Studies: HER2+ Early-Stage Breast Cancer with Ruth O'Regan, MD

Ruth O’Regan, MD, reviews the goals of therapy and treatment options in HER2+ early-stage breast cancer, including neoadjuvant therapy, using case-based scenarios.

HER2+ Early-Stage Breast Cancer with Ruth O'Regan, MD Case 2

Case Scenario 2:

  • This is a 33-year old pre-menopausal woman who, after palpating a mass in her left breast, was referred for a mammogram by her primary care physician. Family history includes a sister who died of breast cancer at age 43 years.
  • Her mammogram revealed a spiculated mass in the upper outer quadrant of the left breast. Targeted ultrasound showed a 2.6 x 3.4 x 2.1 cm irregular mass with an indistinct margin. Prominent appearing right axillary lymph nodes.
     
  • Pathology: core biopsy revealed an invasive ductal carcinoma, poorly differentiated, lymphovascular invasion present. The tumor sample was mammaglobin-positive, ER/PR-negative, and HER2 3+ by IHC. Axillary ultrasound with fine-needle aspiration which was also positive for nodal involvement.
     
  • The case was presented at the breast cancer multidisciplinary tumor board.  The team recommended neoadjuvant therapy before surgery.
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