Optune (NovoTTF-100A) in combination with adjuvant temozolomide has received FDA approval as a treatment for patients with newly diagnosed glioblastoma multiforme following surgery, chemotherapy, and radiation therapy.
Anna C. Pavlick, DO, co-director, Melanoma Program, assistant director, Clinical Research Education, associate professor, Departments of Medicine and Dermatology, Langone Medical Center, New York University, discusses the benefits of biopsying melanoma tissue before treatment to better target therapy.
A more than 25-month improvement in overall survival was seen with lyso-thermosensitive liposomal doxorubicin (LTLD; ThermoDox) combined with optimized (?45 minutes dwell time) radiofrequency ablation in patients with hepatocellular carcinoma.
Telesta Therapeutics has been granted an FDA advisory hearing to discuss the biologics license application of its MCNA immunotherapy as treatment for high-risk nonmuscle invasive bladder cancer following first-line bacillus Calmette-Guerin (BCG).
The immunotherapy, pembrolizumab (Keytruda), has been FDA approved for treatment in patients with pretreated advanced non-small cell lung cancer across all histologies with tumors expressing PD-L1.
Frontline combination treatment with erlotinib and bevacizumab demonstrated high efficacy in patients with advanced non-small cell lung cancer who harbored an EGFR T790M mutation.
Lorraine Pelosof, MD, PhD, assistant professor, Division of Hematology/Oncology, The University of Texas Southwestern Medical Center, discusses targets and possible therapies for never smokers diagnosed with non-small cell lung cancer (NSCLC).
Tasquinimod demonstrated promise in phase II trials but failed to improve overall survival in a phase III trial in treatment-naive metastatic castration-resistant prostate cancer; some experts believe this failure highlights the need for more intelligent clinical trial designs in prostate cancer.