ONCAlert | 2018 SGO Annual Meeting on Women’s Cancer
Colorectal Cancer Case Studies

Charles Fuchs, MD: Treatment Toxicities and Quality of Life

Charles Fuchs, MD
Published Online:Apr 27, 2016
Case 1 examines a 68-year-old man was diagnosed with advanced, unresectable colon cancer has just started treatment with FOLFIRI plus bevacizumab.

Unresectable Colon Cancer with Charles Fuchs, MD and Tanios Bekaii-Saab, MD: Case 1

Unresectable Colon Cancer with Charles Fuchs, MD and Tanios Bekaii-Saab, MD: Case 1
Unresectable Colon Cancer with Charles Fuchs, MD and Tanios Bekaii-Saab, MD: Case 2
Unresectable Colon Cancer with Charles Fuchs, MD and Tanios Bekaii-Saab, MD: Case 1
Unresectable Colon Cancer with Charles Fuchs, MD and Tanios Bekaii-Saab, MD: Case 2


To what extent do you consider treatment effects on patients’ quality of life in advanced/metastatic colon cancer? Are the differences between chemotherapy regimens sufficient enough to inform your choice of combination chemotherapy and bevacizumab?

It's critically important to always consider quality of life issues anytime we're making a treatment decision in colorectal cancer. Certainly recognizing the differences and side effects of FOLFOX and FOLFIRI, you have to deal with the specific patient issues. I remember recently I was meeting a musician who was diagnosed with metastatic colorectal cancer for whom dexterity was an important issue, and so we talked about not using FOLFOX because he was concerned that any development of sensory neuropathy would affect his livelihood. In that circumstance, we would start with the FOLFIRI and he did extremely well, and that made sense.

Some patients may look at the FOLFIRI and say "well I have issues with regard to GI side effects that pre-date my diagnosis of colon cancer and I would prefer not to do FOLFIRI," though I want to emphasize that the rates of diarrhea with FOLFIRI are pretty modest. Some individuals may hear about the chance of hair loss and they may say "look, I don't want to do FOLFIRI. I'd rather do FOLFOX."

So those are the considerations and discussions I'll often have with patients as we think about those quality of life issues.

Unresectable Colon Cancer: Case 1

68-year-old man was diagnosed with advanced, unresectable colon cancer has just started treatment with FOLFIRI plus bevacizumab.

Publications
Copyright © TargetedOnc 2018 Intellisphere, LLC. All Rights Reserved.