ONCAlert | 2018 ASCO Annual Meeting
Hepatocellular Carcinoma Case Studies

Amit Singal, MD: Interventional Radiology and Local/Regional Therapy

Amit Singal, MD
Published Online:Apr 28, 2016
Mario C is a 74-year-old retired steel worker from Allentown, Pennsylvania. His past medical history is notable for hepatitis B virus (HBV) infection (diagnosed in early 1990s)

Unresectable Hepatocellular carcinoma with Amit Singal, MD and Richard Finn, MD: Case 1



How does interventional radiology (IR) figure into the local/regional therapy of this patient with uHCC?

Interventional radiology actually plays a very and central role when delivering locoregional therapy. The choices that we really have for locoregional therapy include chemoembolization, radioembolization, stereotactic total body radiotherapy, and then you also have systemic therapy. The interventional radiologist provides both the chemoembolization and radioembolization in many centers. Compared to systemic therapy, chemoembolization has a much longer survival rate. The median survival when you treat someone with locoregional therapy, such as chemoembolization, the 2 year survival rate goes from 20% up to 60%. This is the best therapy that we have for someone with localized disease to the liver.

CASE 1: Unresectable Hepatocellular Carcinoma (uHCC)

Mario C is a 74-year-old retired steel worker from Allentown, Pennsylvania. His past medical history is notable for hepatitis B virus (HBV) infection (diagnosed in early 1990s).

In July 2013, patient was referred to a hepatologist with an elevated ALT (70 IU/mL) and AST (53 IU/mL).

  • Medical history is also notable for mild hypertension (currently controlled on antihypertensives) and hypercholesterolemia (currently controlled with diet); patient denies any alcohol use
  • Family history was relevant for an older brother who died of HCC and chronic HBV infection at age 70
  • On physical exam, no evidence of liver disease was noted and patient did not report any recent weight loss; patient reported some intermittent abdominal pain and there was mild tenderness in the lower right quadrant on palpation
  • Ultrasound revealed a poorly defined mass in the right lobe; contrast enhanced MRI showed a 12-cm mass in the lower right segment consistent with HCC and several smaller nodules. Bone scan and chest CT showed no evidence of metastatic disease
  • Patient presented to the Multidisciplinary Team (MDT) with Child Pugh Class A, with a MELD score of 7; patient’s performance status was 1
  • On surgical consult, the patient was deemed unresectable and the MDT recommended a TACE procedure for the larger lesion

In December of 2014, evidence of residual disease was detected on a follow up CT scan at the site of the first TACE procedure; smaller nodules also showed evidence of radiologic progression.

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