ONCAlert | 2017 San Antonio Breast Cancer Symposium
Lung Cancer Case Studies

Case Studies: Metastatic Non-Small Cell Lung Cancer with Alexander Drilon, MD

Alexander Drilon, MD, reviews molecular testing, goals of therapy, and treatment options in metastatic non-small cell lung cancer with no actionable mutations using case based scenarios.

Metastatic Non-Small Cell Lung Cancer with Alexander Drilon, MD: Case 1

Casee Scenario 1:

Robert P is a 72 year old retired factory worker from Detroit, Michigan.His medical history is notable for hypertension (well-controlled), hyperuricemia, and gout.

In September of 2015, he presents to his PCP with fatigue, progressive dyspnea, and a persistent, nonproductive cough of approximately 1 month’s duration. He is a former smoker and quit approximately 30 years ago.

  • Chest X-ray in October 2015 showed a large mass in the upper left lobe and CT scan showed a left malignant pleural effusion and enlargement of the right mediastinal and hilar lymph nodes.
  • MRI of the brain was negative for intracranial metastases.
  • The patient underwent resection of the primary mass and biopsy of the affected lymph nodes which showed large cell carcinoma.
  • His lung cancer was staged as 4; Biopsy of the primary lesion and lymph node metastases were sent for molecular testing and showed no actionable mutations in EGFR or ALK.
  • His current performance status is 0.
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