ONCAlert | 2018 ASCO Annual Meeting
Multiple Myeloma Case Studies

Case Studies: IMiD Sequencing in Relapsed Myeloma with Keith Stewart, MB, ChB

Keith Stewart, MB, ChB, reviews the goals of therapy and IMid sequencing in multiple myeloma using case-based scenarios.

IMiD Sequencing in Relapsed Myeloma with Keith Stewart, MB, ChB Case 2

Case Scenario 2:

December 2013

  • The patient is a 77-year old African American male who was diagnosed 24 months ago with stage III multiple myeloma and not eligible for transplant based on his level of frailty. His cytogenetics were classified as intermediate risk.
  • He received treatment with lenalidomide (15 mg daily) and low-dose dexamethasone.

December 2015

  • IgA monoclonal protein spike seen on SPEP. M-protein level has risen to 0.6 g/dl.
  • He continued to do well functionally.
  • Lenalidomide was increased to 25 mg daily.

May 2016

  • The patient now complains of increasing back pain, fatigue and weakness. He was hospitalized two months ago for pneumonia.
  • Abnormal laboratory findings show:
    • Serum beta-2-microglobulin level, 6.2 mg/L
    • Albumin level of 2.1 g/dL.
    • Creatinine clearance of 32 ml/min
  • Skeletal survey shows lytic lesions in the L4/L5 vertebrae.
  • Bone marrow biopsy shows 30% involvement by abnormal appearing plasma cells, confirmed by CD138+ IHC stain.
  • ECOG performance status is 2.
  • The patient was started on pomalidomide, weekly cyclophosphamide, and low-dose dexamethasone.
Publications
Copyright © TargetedOnc 2018 Intellisphere, LLC. All Rights Reserved.