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ONCAlert | 2018 SGO Annual Meeting on Women’s Cancer
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Lung Cancer Screening Rates Remain Inadequate, Despite Recommendations

Gina Columbus
Published Online:2:29 PM, Thu May 17, 2018

Danh Pham, MD
Despite recommendations from the United States Preventative Services Task Force (USPSTF), 1.9% of the 7.6 million current and former heavy smokers underwent cancer screening in 2016, suggesting screening is still inadequate. These results were presented ahead of the 2018 ASCO Annual Meeting being held in Chicago, Illinois on June 1-5, 2018.

In 2013, the current USPSTF recommendations were relased, calling for annual low-dose CT scans in patients 55-80 years old that are either current or former heavy smokers. This is defined as smoking ≥30 cigarette-pack years. A joint guideline was issued by ASCO and the American College of Chest Physicians in 2012 with similar opinions. The Centers for Medicare and Medicaid Services (CMS) also expanded Medicare coverage to include low-dose CT scans for lung cancer screening.

“Despite the time since implementation and the potential to prevent thousands of lung cancer deaths every year, annual low-dose CT scanning is only at 1.9% nationally, which remains inadequate following these USPSTF recommendations, especially when it compares to other known screenings in cancer,” said lead study author Danh Pham, MD, a medical oncologist of James Graham Brown Cancer Center at the University of Louisville, during a presscast prior to the meeting.

Current data provided estimates of lung cancer screening since US execution, leading to Pham’s et al statistical analysis, which is the first assessment of lung cancer screening rates since those guidelines were issued and subsequent insurance coverage.

In the study, researchers used data from the 2016 American College of Radiology’s Lung Cancer Screening Registry of people who received low-dose CT scans across the radiographic screening sites. These data were then compared with findings from the 2015 National Health Interview Survey, which estimates the number of eligible smokers to be screened, as per the USPSTF recommendations. Moreover, data were compared between 4 US census regions of Northeast, West, Midwest, and South; the analysis excluded those without a history of lung cancer and patients with missing data.

Overall, results showed that while a total 1796 screening centers could have screened 7,612,975 current and former heavy smokers, only 141,260 people underwent low-dose CT scans, leading to a 1.9% national screening rate. Screening rates were calculated by dividing the number of low-dose CT scans by the number of eligible smokers for screening as per the standard recommendations.

Data showed that the Northeast had the highest screening rate at 3.5% (40,105 scans) followed by the Midwest at 1.9% (38,931). The Northeast and Midwest regions had 404 and 497 screening sites, as well as 1,152,141 and 2,020,045 eligible smokers, respectively.

Moreover, the South region had 663 accredited screening sites, the largest of the 4 regions, and the highest number of smokers eligible for screening (3,072,095). However, the screening rate here was 1.6% (47,966), determined to be the second-lowest screening rate in the country.

In the West, findings showed that this region had the lowest number of accredited screening sites (232), as well as the lowest screening rate at 1.0%. This region had 1,368,694 eligible smokers and 14,080 were screened.

“This ultimately begs the question on the root of the disparity: are physicians not referring enough, perhaps?” asked Pham. “Or, are eligible patients not wanting screening—even if they knew a test was available? Controversy, unfortunately, exists amongst providers…while patients at risk for lung cancer also perhaps lack the adequate awareness of the benefits of screening.”

Additionally, 85% of the current smokers who did have low-dose CT scans were offered smoking cessation resources. There was not a significant difference when compared across census regions.

The authors noted that it remains unclear why the lung cancer screening rate is significantly less than that of other cancer screening modalities. For example, Pham said, approximately 65% of women ≥40 years had a mammogram in 2015.

“It’s still speculation at this point, but lung cancer is particularly unique in that there may be a stigma associated with screening, in that [lung] cancer is attributed to modifiable risk factors through heavy smoking,” Pham explained. “The at-risk population may be deterred from wanting screening if diagnosing cancer will result in confirming a poor lifestyle choice.”

Preliminary findings of 2017 lung cancer screening rates show a small uptick across all census regions. Forward-thinking initiatives, said Pham, include awareness programs and mandatory lung cancer screening as a national quality measure. Effective screening can prevent 12,000 premature lung cancer deaths annually, he concluded.

“Regardless of whatever the reason, this ultimately is a call to action in everyone’s part to increase the much-needed screening, whether it’s through increasing awareness or conducting additional research to urgently increase the screening of the number one cancer killer in America.”

Bruce E. Johnson, MD, FASCO, ASCO president, and co-moderator of the presscast, noted that these findings do reflect data of the lung cancer screening after being covered under Medicaid for 1 year, but that it does signify a need for change in screening awareness.

“It is very disappointing how uncommon this,” added Johnson, who is also professor of medicine at Harvard Medical School, and of adult oncology at Dana-Farber Cancer Institute. “It should be saving 12,000 and, with this number, it’s about 250 people instead of 12,000 a year.”

Lung cancer remains the leading cause of cancer-related mortality in the United States with an estimated 154,050 deaths expected in 2018. Results of the National Lung Cancer Screening Trial in 2011 showed a 20% lower risk of lung cancer mortality with low-dose CT scan, Pham said.

Richard L. Schilsky, MD, FACP, FASCO, chief medical officer of ASCO and co-moderator of the presscast, said to keep in mind that cancer screening is generally performed by primary care physicians as opposed to oncologists.

“One thing that we need to do is to make sure that primary care providers are well aware of the screening data and the importance of referring the appropriate patients for screening—and to be aware of the screening centers available in their communities.”
 
Reference:
Pham D, Bhandari S, Oechsli M, et al. Lung cancer screening registry data reveals very low screening rate. J Clin Oncol. 2018;36 (suppl; abstr 6504).


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