An Overview of ABT-199 for the Treatment of CLL
Jennifer Brown, MD, PhD, Director, Chronic Lymphocytic Leukemia Center, Dana-Farber Cancer Institute, Assistant Professor of Medicine, Harvard Medical School, discusses the Bcl-2 inhibitor ABT-199 for the treatment of patients with CLL.
Clinical Pearls
Jennifer Brown, MD, PhD, Director, Chronic Lymphocytic Leukemia Center, Dana-Farber Cancer Institute, Assistant Professor of Medicine, Harvard Medical School, discusses the Bcl-2 inhibitor ABT-199 for the treatment of patients with chronic lymphocytic leukemia (CLL).
- ABT-263 demonstrated significant activity in CLL, though caused thrombocytopenia
- ABT-199 has not had thrombocytopenia issues, but is so potent that it has had problems with tumor lysis
- ABT-199 demonstrated an 80-85% nodal response in an ongoing phase I trial (52 patients)
- All 52 patients in the trial experienced a 50% reduction in lymphocyte count
- ABT-199 has demonstrated efficacy in patients with a 17p deletion and may clear bone marrow more effectively than kinase inhibitors
Landgren on MRD as an End Point for Multiple Myeloma Trials
May 1st 2024C. Ola Landgren, MD, PhD, discussed the FDA’s unanimous ODAC vote supporting minimal residual disease as an accelerated approval end point in multiple myeloma and the implications of this vote in the myeloma research field.
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