Frederick L. Locke, MD, discusses how chimeric antigen receptor (CAR) T-cell therapies have evolved over the last 30 years of research in the field of hematologic malignancies.
Frederick L. Locke, MD, medical director and research director of the Immune Cell Therapy Program and the co-program leader of the Immunology Program, vice chair of the Blood and Marrow Transplant and Cellular Immunotherapy program at Moffitt Cancer Center, discusses how chimeric antigen receptor (CAR) T-cell therapies have evolved over the last 30 years of research in the field of hematologic malignancies.
Early work with CAR T cells demonstrated their capabilities in animal models, but it wasn’t until second-generation CAR T cells were introduced that the real benefit for patients was seen in larger, multicenter trials, such as the ZUMA-1 trial that led to the approval of axicabtagene ciloleucel (axi-cel; Yescarta) in patients with large B-cell lymphomas, Locke said.
Enhancing Precision in Immunotherapy: CD8 PET-Avidity in RCC
March 1st 2024In this episode of Emerging Experts, Peter Zang, MD, highlights research on baseline CD8 lymph node avidity with 89-Zr-crefmirlimab for the treatment of patients with metastatic renal cell carcinoma and response to immunotherapy.
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