Nazli Dizman, MD, explains that gut microbiome diversities play a large role in modulating response to immunotherapy.
Nazli Dizman, MD, an Internal Medicine resident at Yale Department of Internal Medicine, discusses the role of gut microbiome diversities in cancer.
According to Dizman, gut microbiome diversities play a large role in modulating response to immunotherapy and the more diverse, the better. Within several cancer types, including renal cell carcinoma (RCC), microbial diversity is associated with better outcomes for patients.
Advancements in research have allowed investigators to better understand the microbiomes impact on clinical outcomes. In patients with RCC, better progression free survival and higher rates of response have been shown.
Transcription:
0:08 | Gut microbiome diversities are playing an important role in modulating one's response to immunotherapy as a diverse microbiome is a better microbiome. There are also a few other species that were shown to be associated with response immunotherapies and targeted therapies too such as akkermansia muciniphila which has shown to be associated with better outcomes with immunotherapies in several cancer types, including renal cell carcinoma. Bacterial species are associated with worse outcomes when they are abundant in one school.
0:54 | Overall, there's still inconsistencies across different studies in terms of the association between certain species and the outcomes, but what is consistent across studies is the microbiome diversity. In my presentation, I also mentioned that antibiotics may have detrimental roles in a patient's response to immunotherapies again, and even with targeted therapies, we have some evidence showing their role as a determinant of response. It doesn't mean that we should refrain from antibiotics, but we should be using them very mindfully. Beyond that, now we have techniques to modulate gut microbiome.
Key Takeaways From QOL and Use of Steroids With IO-Based RCC Regimens
May 6th 2024During a Case-Based Roundtable® event, Ulka Vaishampayan, MBBS, discussed the safety and quality-of-life data for ipilimumab plus nivolumab in patients with advanced renal cell carcinoma in the second article of a 2-part series.
Read More
Enhancing Precision in Immunotherapy: CD8 PET-Avidity in RCC
March 1st 2024In this episode of Emerging Experts, Peter Zang, MD, highlights research on baseline CD8 lymph node avidity with 89-Zr-crefmirlimab for the treatment of patients with metastatic renal cell carcinoma and response to immunotherapy.
Listen
Comparing Choices for IO/TKI Combinations in Advanced RCC
May 2nd 2024During a Case-Based Roundtable® event, Shilpa Gupta, MD, led a discussion on the combination of immunotherapy and tyrosine kinase inhibitors for patients with advanced renal cell carcinoma in the second article of a 2-part series.
Read More
Beyond the First-Line: Economides on Advancing Therapies in RCC
February 1st 2024In our 4th episode of Emerging Experts, Minas P. Economides, MD, unveils the challenges and opportunities for renal cell carcinoma treatment, focusing on the lack of therapies available in the second-line setting.
Listen
Sustained Treatment-Free Survival in RCC Seen With Nivolumab and Ipilimumab
April 30th 2024Nivolumab monotherapy plus salvage nivolumab/ipilimumab demonstrated superior treatment-free survival rates among patients with advanced renal cell carcinoma, especially in patients with favorable risk profiles.
Read More
Roundtable Roundup April: Renal Cell Carcinoma
April 27th 2024In separate, live virtual events, Arnab Basu, MD, MPH, and Robert J. Motzer, MD, asked participants which therapy they would choose for a patient with clear cell renal cell carcinoma (RCC) and why they would make that choice.
Read More