What is the risk:benefit of using ifosfamide in this patient?
Patients with metastatic or unresectable leiomyosarcoma are often treated with chemotherapy initially. That is usually an anthracycline-based regimen as frontline therapy. The anthracycline appears to be more active when used in combination.
In our practice, we use either ifosfamide or
, particularly in patients with uterine tumors. Patients with leiomyosarcoma arising outside of the uterus do not showcase exactly how ifosfamide adds to an anthracycline well enough.
dacarbazine
CASE: Soft-Tissue Sarcoma (Part 1)
Rachel F is a 58-year-old school teacher from Roanoke, Virginia. Her medical history is notable for mild hypertension and total knee replacement in 2011
Follow-up CT scan in January 2014 showed progression at multiple sites; at the time of follow up, her ECOG performance status was 1, with renal and hepatic function within normal limits
In September of 2014 she returns for follow-up, unable to work with increasing fatigue and abdominal pain, and her CT scan was consistent with progressive disease
After 4 months of therapy, she presents with worsening abdominal pain and declining performance status
Need for Systemic Therapy Remains in Sarcoma
November 27th 2023In an interview with Targeted Oncology, Lisa B. Ercolano, MD, discussed the evolving treatment landscape for sarcomas and underscored the pivotal role of molecular profiling, while addressing the need for more efficacious systemic therapies.
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