Neal Shore, MD, FACS discusses results from a post-hoc analysis of the phase 3 ARCHES trial.
Neal Shore, MD, FACS the US chief medical officer of Surgery and Oncology at GenesisCare and the director and certified principal investigator at the Carolina Urologic Research Center, discusses results from a post-hoc analysis of the phase 3 ARCHES trial (NCT02677896). The analysis assessed overall survival in patients with prior local therapy, defined as previous radical prostatectomy and/or radiation therapy to the prostate area.
The results were presented during a moderated poster session at the AUA 2022 Annual Meeting, in New Orleans, LA. The analysis demonstrated that enzalutamide (enza; Xtandi) plus androgen deprivation therapy (ADT) improved recurrence-free survival (RFS) and OS vs ADT alone in patients with metastatic hormone-sensitive prostate cancer (mHSPC). The hazard ratio for the difference between enza plus ADT vs ADT alone was 0.66 (95% CI, 0.53, 0.81; P <0.0001).
According to Shore, in terms of OS and RFS, patients with de novo or recurrent mHSPC did better with the combination, and the positive findings were irrespective of prior treatment with either surgery or radiation, Shore adds.
0:08 | I think the most important thing to highlight is that if you have patients who have either de novo mHSPC, or recurrent mHSPC, whether they've had an active treatment for the primary, the prostate, whether it was a surgical extirpation or radiation or both, regardless [of] when they go on to develop metastatic disease.
0:33 | The patients did remarkably better from an RFS and OS standpoint for those who received combination ADT and enza versus monotherapy ADT.
First Real-World Data on Second-Generation AR Inhibitor Use in nmCRPC
September 18th 2023A review of real-world data from the DEAR study of darolutamide, enzalutamide and apalutamide for the treatment of nonmetastatic castration-resistant prostate cancer is given by Alicia Morgans, MD, MPH.
Listen
Responders to UGN-101 Have Positive RFS in Upper Tract Urothelial Cancer
May 5th 2024In patients at 15 centers who had upper tract urothelial cancer, those with no evidence of disease after UGN-101 induction had a 68% rate of 3-year recurrence-free survival, and this outcome did not differ based on tumor status, method of instillation, or treatment intent.
Read More