Recurrent Cutaneous Squamous Cell Carcinoma

Case: A 74-Year-Old Male With Recurrent Metastatic CSCC

November 2017

• A 74-year-old male from Florida, with history of multiple resections of CSCC on neck, back and shoulders presents with new deep lesion that exhibited perineural invasion and c/o palpable left axillary mass
• Imaging confirmed 6cm left axillary nodal conglomerate
• Patient treated with neoadjuvant cisplatin/5FU for 3 cycles
• Surgical resection of primary lesion; Lymphadenectomy revealed CSCC involvement in 12 out of 16 resected lymph nodes

May 2018

• Follow-up scans revealed early disease progression with multiple pulmonary nodules
• Patient started on carboplatin/paclitaxel for 3 cycles

November 2018

• Repeat imaging showed disease progression in pulmonary nodules and multiple lymphadenopathies; mediastinal, left and right axillary; bone metastases
• Patient started on cemiplimab for 3 cycles

February 2019

• Reimaging PET-CT revealed reduction in size and metabolic activity of right and left axillary, and mediastinal lymphadenopathies; pulmonary nodules had considerable reduction in size and were no longer substantial