Manish A. Shah, MD, discusses the results from the randomized phase III GAMMA-1 trial looking at andecaliximab in patients with untreated HER2-negative gastric or gastroesophageal junction adenocarcinoma.
Manish A. Shah, MD, director of Gastrointestinal Oncology and chief of Solid Tumor Service at Weill Cornell Medicine/NewYork-Presbyterian Hospital, discusses the results from the randomized phase III GAMMA-1 trial looking at andecaliximab in patients with untreated HER2-negative gastric or gastroesophageal junction (GEJ) adenocarcinoma.
Overall, the results were disappointing, Shah says. While andecaliximab demonstrated an improved overall response rate, there was no improvement in progression-free survival or overall survival in the unselected patient population. However, patients over the age of 65 seemed to have benefit.
Investigators conducted a sensitivity analysis and split the groups according to age to see if there was a step-wise increased benefit with the youngest group to the oldest. Shah says there was, suggesting there may be a signal here. More work must be done in order to find factors that may lead to this specific sensitivity in the older patient population, Shah concludes.
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