The Challenges of Measuring Tumor Heterogeneity
Ari Melnick, MD, a professor of medicine at the Weill Cornell Medical College, discusses the challenges associated with measuring tumor heterogeneity.
Clinical Pearls
Ari Melnick, MD, a professor of medicine at the Weill Cornell Medical College, discusses the challenges associated with measuring tumor heterogeneity.
- Measuring variability requires looking at many methylated sites in the genome, which is unlikely to become a routine test
- There remains a need for a way to measure tumor heterogeneity in a reliable and meaningful way
- Researchers are currently looking for si​tes in the genome that may be a surrogate marker for genome-wide profiling
- It is impossible to target diversity from the genetic standpoint, though epigenetic diversity could be targeted
- Hypothetically, drugs could demethylate the genome to make it more uniform
Examining the Non-Hodgkin Lymphoma Treatment Paradigm
July 15th 2022In season 3, episode 6 of Targeted Talks, Yazan Samhouri, MD, discusses the exciting new agents for the treatment of non-Hodgkin lymphoma, the clinical trials that support their use, and hopes for the future of treatment.
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Brain Cancer Awareness Month: Challenges and Innovations in Treatment
May 13th 2024In an interview with Targeted Oncology for Brain Cancer Awareness Month, Theodore Schwartz, MD, discussed the challenges of targeting brain tumors, emerging therapies, and strategies to overcome the blood-brain barrier.
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