May 14th 2024
The phase 2 VERSATILE-002 trial evaluating Versamune HPV with pembrolizumab met its primary end point in patients with first-line recurrent metastatic head and neck squamous cell cancer.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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Novel Nanocarrier Could Penetrate Blood-Brain Barrier in Glioblastoma
November 20th 2015A team of scientists have conducted preclinical trials of a novel drug nanocarrier, 3HM, that may offer a solution to breaking the blood-brain barrier in the treatment of brain cancers like glioblastoma multiforme.
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Scientists Uncover Potential TMZ-Resistance Reversal in Glioblastoma
November 20th 2015A team of scientists from Virginia Tech Carilion Research Institute and clinicians from Carilion Clinic may have found a way to increase sensitivity to the front-line chemotherapeutic agent temozolomide (TMZ) in glioblastoma (GBM), even after resistance.
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Researchers Investigating Less Intense Treatment for HPV-Positive Oropharyngeal Cancers
November 6th 2015With the incidence of HPV-positive oropharyngeal cancers on the rise, researchers are currently seeking less intense treatment options that combine effectiveness and low toxicity for patients.
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Advanced Thyroid Cancer Responds Well to Targeted Therapies
November 6th 2015The kinase inhibitors sorafenib (Nexavar) and lenvatinib (Lenvima) have significantly altered the treatment paradigm for patients with advanced radioactive iodine (RAI)-refractory differentiated thyroid cancer in both older and younger populations, with combination strategies hoping to further build upon this success.
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Tropomyosin-Related Kinases (TRK) Making Headway in Head and Neck Cancer
November 3rd 2015Treatment of certain head and neck cancers may soon be fundamentally transformed through the use of molecular diagnostics to dissect essential oncogenic driver pathways, and ultimately to identify targeted therapies that specifically inhibit them.
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Dr. Baumann on Hypoxia-Specific PET Imaging in Head and Neck Cancer
October 10th 2015Michael Baumann, MD, Professor of Radiation Oncology, Director University of Dresden Cancer Center in Dresden, Germany discusses the DDFMISO-trial, which investigated hypoxia-specific PET imaging during radio-chemotherapy for locally advanced head-and-neck cancer.
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Oncolytic Vaccines With Chemotherapy Show Survival Benefit in Head and Neck Cancer
September 15th 2015The attenuated vaccinia virus, GL-ONC1, demonstrated safety and clinical benefit when delivered intravenously with concurrent chemoradiation therapy in patients who have locoregionally advanced head and neck carcinoma (LA-HNC).
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Dr. Taylor Discusses the Toxicities and Impact of Lenvatinib in the SELECT Trial
September 1st 2015Matthew H. Taylor, MD, Oregon Health and Science University, discusses the toxicities and impact of lenvatinib in the SELECT trial, which treated patients with 131I-refractory differentiated thyroid cancer.
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DNA Immunotherapy Candidate for Head & Neck Cancer Part of New Pharma Collaboration
August 14th 2015AstraZeneca’s MedImmune has entered into a licensing agreement and collaboration with Inovio Pharmaceuticals, whereby MedImmune was given exclusive rights to Inovio’s INO-3112 immunotherapy.
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Afatinib Versus Erlotinib in Advanced SCC of the Lung
June 24th 2015Shirish Gadgeel, MD, Barbara Ann Karmanos Cancer Institute, discusses a phase III study examining afatinib versus erlotinib as a second-line treatment of patients with advanced squamous cell carcinoma (SCC) of the lung following first-line platinum-based chemotherapy.
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A Little STING May Enhance the Immune System Against Cancer
April 25th 2015Despite their promise, checkpoint inhibitors are not effective in every patient, and research suggests the STING (stimulator of interferon genes) pathway may hold important clues as to why some tumors fail to respond.
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Dinutuximab Approved for High-Risk Neuroblastoma
March 10th 2015Dinutuximab (Unituxin) has been approved by the FDA in combination with interleukin-2, granulocyte-macrophage colony-stimulating factor (GM-CSF), and isotretinoin as a frontline therapy for pediatric patients with high-risk neuroblastoma.
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Thyroiditis in Melanoma Patient Treated With Ipilimumab and Pembrolizumab
March 7th 2015In an analysis of adverse events following treatment of patients with advanced melanoma with ipilimumab and nivolumab, combination therapy was associated with a 22% incidence of either thyroiditis or hypothyroidism and a 9% incidence of hypophysitis.
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Rindopepimut Gains Breakthrough Designation for EGFRvIII-Positive Glioblastoma
February 23rd 2015The FDA has granted rindopepimut (Rintega) a Breakthrough Therapy Designation for the treatment of adult patients with glioblastoma multiforme (GBM) that test positive for the epidermal growth factor receptor (EGFR) variant (EGFRvIII).
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