May 2nd 2024
Acalabrutinib plus bendamustine and rituximab bettered progression-free survival over bendamustine and rituximab alone in patients with untreated mantle cell lymphoma.
Community Practice Connections™: Real-World Applications of Novel Therapies Across TNBC and Addressing Disparities in Care
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6th Annual Precision Medicine Symposium: An Illustrated Tumor Board
October 18-19, 2024
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Advances in TNBC: Communicating with Your Patients About Clinical Trial Awareness and Treatment Concerns to Improve Clinical Outcomes
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Community Practice Connections™: 5th Annual Precision Medicine Symposium – An Illustrated Tumor Board
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A Look Back at FDA News in the Month of March
April 3rd 2018Several new indications were approved by the FDA in March, including blinatumomab (Blincyto) for MRD+ ALL, brentuximab vedotin (Adcetris) for Hodgkin lymphoma, and a 4-week nivolumab (Opdivo) dosing schedule across several indications. Here’s a look back on the FDA happenings for the month of March 2018.
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Wang Discusses Treatment Options for Patients With Intermediate-Risk Mantle Cell Lymphoma
March 15th 2018Michael L. Wang, MD, explains the biologic underpinnings of MCL as well as the treatment options for patients with MCL. The discussion is based on a case scenario of a patient with stage III intermediate-risk disease, and the factors that Wang would use when choosing the best treatment regimen for this patient.
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Ibrutinib Continues to Showcase Efficacy as MCL Therapy
March 15th 2018Ibrutinib continues to be the standard of care for the treatment of relapsed/refractory patients with mantle cell lymphoma since its FDA approval in 2013, and long-term follow-up data of the Bruton's tyrosine kinase (BTK) inhibitor continue to demonstrate its clinical activity. In this interview with Targeted Oncology, an expert in the field sheds light on the impact of BTK inhibition on the treatment landscape.<br />
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Emerging Treatment Strategies in MCL
March 14th 2018The potential synergy of new agents with other treatment strategies, including immunotherapeutic and targeted approaches, is currently being investigated in various clinical trials, with the hope of identifying combinations that will lead to longer responses and improvements in duration of response for patients with MCL.
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Current Treatment Strategies in MCL
March 14th 2018Effective management of mantle cell lymphoma requires awareness of current therapeutic approaches for a wide range of patient populations, clinical trials supporting the use of therapy in the frontline or relapsed/refractory settings, newer therapeutic options and strategies, and emerging therapies to improve patient outcomes​​​​​​.
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Diagnosis, Staging, and Risk in MCL
March 14th 2018Due to the diversity of disease presentation, together with new iterations of guidelines for MCL diagnosis, staging, and risk, there is no standardized therapeutic approach. Treatment decisions are currently guided by several factors, including patient age, level of fitness, presence of symptoms, risk category, proliferative index, and cell variant, which means it is important to accurately diagnose, stage, and assess risk in patients with MCL
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Umbralisib Shows Encouraging Early Activity in CLL and Lymphoma
February 23rd 2018According to phase I findings published in <em>The Lancet Oncology,</em> an objective response rate of 37% was induced in patients with relapsed/refractory lymphoma or chronic lymphocytic leukemia treated with the PI3K-delta inhibitor umbralisib.
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Long-Term Follow-Up Results From the ZUMA-1 Trial in Non-Hodgkin Lymphoma
February 23rd 2018Sattva S. Neelapu, MD, associate professor, Department of Lymphoma/Myeloma, Division of Cancer Medicine, at The University of Texas MD Anderson Cancer Center, discusses long-term findings of the ZUMA-1 trial investigating axicabtagene ciloleucel (axi-cel; Yescarta) in patients with refractory aggressive non-Hodgkin lymphoma.
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Liso-Cel Demonstrates "Remarkable" Activity, Lower Toxicity in Patients With DLBCL
February 22nd 2018Treatment with the CD19-targeted chimeric antigen receptor T-cell therapy lisocabtagene maraleucel (liso-cel, formally known as JCAR017) demonstrated a complete response rate of 63% and an objective response rate of 81% in patients with relapsed/refractory diffuse large B-cell lymphoma.
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Andrew Evens Joins Rutgers Cancer Institute of New Jersey and RWJBarnabas Health
February 7th 2018Lymphoma expert Andrew M. Evens, DO, MSc, FACP, has joined Rutgers Cancer Institute of New Jersey as associate director. He is also serving as medical director of the oncology service line at RWJBarnabas Health. Evens will focus on integrated cancer care delivery in his roles across both institutions.
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Expert Discusses Promising Efficacy of Oral Azacitidine in High-Risk Lymphoma
January 22nd 2018Peter Martin, MD, discusses a phase I, open-label, multicenter trial of oral azacitidine (Vidaza) plus R-CHOP in people with high-risk, previously untreated DLBCL, grade 3B follicular lymphoma, or transformed lymphoma.
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Azacitidine Plus R-CHOP in High-Risk DLBCL
January 18th 2018Peter Martin, MD, assistant professor of medicine in the Division of Hematology/Oncology at Weill Cornell Medical College, Weill Cornell Medicine/NewYork-Presbyterian Hospital, discusses a phase I, open-label, multicenter trial of oral azacitidine (CC-486) plus R-CHOP in patients with high-risk, previously untreated diffuse large B-cell lymphoma, grade 3B follicular lymphoma, or transformed lymphoma.
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Expert Discusses Treatment Options for Patients with MCL Based on 2 Case Scenarios
January 17th 2018Mitchell R. Smith, MD, PhD, recently shared both the more and less intensive treatment considerations he makes when treating patients with MCL and the major factors that influence them. Smith explained such considerations based on 2 case scenarios during a <em>Targeted Oncology</em> live case-based peer perspectives presentation.
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Dr. Goy Discusses Long-Term Follow-Up Results for Ibrutinib in MCL
December 14th 2017Andre Goy, MD, chairman and director, chief of Lymphoma, and director of Clinical and Translational Cancer Research at John Theurer Cancer Center, Hackensack Medical Center, discusses long-term follow-up results for ibrutinib (Imbruvica) in relapsed/refractory mantle cell lymphoma.
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Expert Reflects on Acalabrutinib Approval in MCL and Next Steps With the Agent
December 14th 2017Michael Wang, MD, discusses the impact of acalabrutinib on patients with MCL, ongoing progress in the field, and The University of Texas MD Anderson Cancer Center’s Lymphoma Moonshot Program.
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Cemiplimab Monotherapy Induces 50% ORR in Hodgkin Lymphoma
December 13th 2017Treatment with the novel PD-1 inhibitor cemiplimab induced responses in half of the patients with Hodgkin lymphoma in a phase I study of patients with B-lymphoid malignancies; among patients with B-cell non-Hodgkin lymphoma treated with the monotherapy, the overall response rate was 11.1%, according to a poster presentation at the 2017 ASH Annual Meeting.
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Impressive Responses Seen With Tisagenlecleucel in DLBCL in JULIET Trial
December 13th 2017Treatment with tisagenlecleucel (Kymriah) continues to excite the possibilities seen with chimeric antigen receptor T-cell therapy with impressive responses seen with the therapy in patients with relapsed/refractory diffuse large B-cell lymphoma. In the phase II JULIET trial, an overall response rate of 53.1% was observed, according to findings presented at the ASH Annual Meeting.
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Pembrolizumab Receives FDA's Priority Review in PMBCL
December 12th 2017Pembrolizumab (Keytruda) has received a priority review from the FDA for a supplemental biologics license application (sBLA) for the treatment of adult and pediatric patients with relapsed/refractory primary mediastinal large B-cell lymphoma (PMBCL), according to a press release from Merck, the manufacturer of pembrolizumab. The findings were first presented at the 14th International Conference on Malignant Lymphoma and updated data were recently presented at the 2017 ASH Annual Meeting.
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Brentuximab Vedotin/AVD Combo Upfront Improves Outcomes in Hodgkin Lymphoma
December 11th 2017The addition of brentuximab vedotin (Adcetris) to doxorubicin, vinblastine, and dacarbazine (A+AVD) reduced the risk of progression and death by 23% in patients with advanced-stage Hodgkin lymphoma (HL) compared with standard ABVD (doxorubicin [Adriamycin], bleomycin, vinblastine, and dacarbazine) chemotherapy, according to results of the phase III ECHELON-1 clinical trial.
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MAVORIC Study Shows Survival Improved With Mogamulizumab in CTCL
December 10th 2017Mogamulizumab improved progression-free survival in previously treated patients with cutaneous T-cell lymphoma by 4.6 months compared with vorinostat (Zolinza), according to findings from the phase III MAVORIC study.
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Initial and Maintenance Treatment With Rituximab/Lenalidomide Combo Effective, Safe in MCL
December 10th 2017For patients with mantle cell lymphoma, initial and maintenance treatment with the combination of lenalidomide (Revlimid) and rituximab (Rituxan) were found to be feasible, safe, and elicit clinical activity.
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Mogamulizumab Receives FDA's Priority Review for CTCL
November 29th 2017A biologics license application for mogamulizumab has been granted a priority review by the FDA for the treatment of patients with cutaneous T-cell lymphoma who have received at least 1 prior systemic therapy, Kyowa Hakko Kirin, the manufacturer of the anti-CCR4 monoclonal antibody, has announced.
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FDA-Approved Agents for the Treatment of MCL
November 15th 2017Owen O'Connor, MD, PhD, professor of medicine and Experimental Therapeutics, director of the Center for Lymphoid Malignancies, Herbert Irving Comprehensive Cancer Center at Columbia University Medical Center, discusses the agents approved by the FDA for the treatment of mantle cell lymphoma (MCL), including acalabrutinib (Calquence) and bortezomib (Velcade).
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Survival Prolonged in MCL With Maintenance Rituximab Following ASCT
November 15th 2017According to results from the phase III phase III LyMa trial published in the <em>New England Journal of Medicine, </em>survival was improved for patients with mantle cell lymphoma with maintenance rituximab (Rituxan) following autologous stem-cell transplantation (ASCT).
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