The Journal of Targeted Therapies in Cancer

The RAS-RAF-MEK-extracellular signal–regulated kinase 1 and 2 (ERK1/2) pathway is the most mutated pathway in human cancer. Thus, components of this pathway have been seen as promising targets for cancer therapy.
The Journal of Targeted Therapies in Cancer discussed various issues regarding new and existing therapies in breast cancer with Richard Finn, MD.
Treatments for triple-negative breast cancer (TNBC) have made significantly less progress in comparison with other subtypes.
Monoclonal antibodies (mAbs) that target key “restricted” antigens in cancer cells have become an integral part of the management of multiple hematologic and solid tumor malignancies.
Eribulin mesylate has demonstrated clinical benefit as a first-line therapy for locally recurrent or metastatic HER2- negative breast cancer, according to results of a phase II, multicenter, single-arm study.
Significant developments in research and treatment for HER2-positive breast cancer have emerged over the past year. Those advances include a growing number of studies measuring the effectiveness of dual agents.
Anti-angiogenic therapy aims to disrupt blood supply to tumors and has proven clinical benefit in nonsquamous non-small cell lung cancer (NSCLC).
JTT Articles
Afatinib for EGFR Mutation-Positive, Advanced Non-Small Cell Lung Cancer
Eribulin Shows First-Line Activity in MBC
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